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It is one of four known caffeinated holly trees, and the leaves are made as a tea either fresh or dried.
Jivaroan peoples in Ecuador and Peru also prepare a drink from the leaves to be drunk in large amounts during pre-dawn ceremonies that involve the vomiting of the excess drink to wash out the stomach and small intestine to avoid absorbing too much caffeine.
A ritual use by the Quechua people involves drinking guayusa infusion to have foretelling dreams for successful hunting expeditions.
Ilex Guayusa is also consumed at parties and local festivals as a social drink, especially by the Kichua people in Ecuador and can even be used in the preparation of artisanal alcoholic drinks.