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In Egypt Opium Lettuce was thought to be good for eye complaints and an aphrodisiac since it was regarded as the favourite plant of the fertility deity Min.
Lactuca virosa was used in the 19th century by physicians when opium could not be obtained. It was studied extensively by the Council of the Pharmaceutical Society of Great Britain in 1911. They discovered two chemicals responsible for the properties of L. virosa; lactucopicrin and lactucin.
Its dried leaves can be smoked or brewed in to a tea, to provide mild sedative effects. It should not be confused with opium poppies which contain codeine, which can be dangerous if over-consumed.